Karen (Jill Talley) is Plankton's nagging computer "WIFE" (as in an acronym for "Wired Integrated Female Electroencephalograph") and voice of reason. She apparently has a mind of her own to the point of making fun of Plankton. Karen usually helps Plankton in his schemes to steal the Krabby Patty secret

formula, although on occasions Plankton rejects her ideas and then takes them as if they were his own. She has a sarcastic attitude towards Plankton, and it is revealed in The SpongeBob SquarePants Movie that she never agreed to marry Plankton. Karen also made a cameo in an episode of The Fairly OddParents called "Love Triangle," in which Karen is the monitor at the hospital after Foop catches a disease.